Network pharmacology analysis and molecular docking verification of the mechanism of Zhenqi Fuzheng Capsule in the adjuvant treatment treatment of AIDS / 国际中医中药杂志

Objective:To analyze the molecular mechanism of Zhenqi Fuzheng Capsules in the adjuvant treatment of AIDS by network pharmacology method and molecular docking technology.Methods:The active components and targets of Zhenqi Fuzheng Capsules were obtained through TCMSP, and the AIDS-related targets were obtained through GeneCards, OMIM and DrugBank databases. The intersection target PPI network was constructed through STRING 11.5 database, and Cytoscape 3.9.1 software was used for network topology analysis; Metascape database was used for GO function and KEGG pathway enrichment analysis of core targets; Cytoscape 3.9.1 was used to construct Zhenqi Fuzheng Capsules component-target-pathway network; Autodock Tools software was used to carry out molecular docking of core targets and active components.Results:Totally 31 active components and 180 targets of Zhenqi Fuzheng Capsules were screened out. TNF, IL6, AKT1, IL1B, TP53, VEGFA, RELA, EGFR and CASP3 were identified as the core targets. GO functional enrichment analysis obtained 1 436 biological processes, 53 cellular components, and 117 molecular functions. KEGG pathway enrichment analysis obtained 167 pathways, which were related to pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, and IL-17 signaling pathway was closely related. Molecular docking results showed that core targets such as AKT1 and TNF had good binding activity to quercetin, kaempferol, and luteolin.Conclusion:The main active components of Zhenqi Fuzheng Capsules in the adjuvant treatment of AIDS are quercetin, kaempferol and luteolin, which may treat AIDS through the IL-17 signaling pathway.

Discussion on astronomical background of yiyi calenders chronological era by heavenly stems and earthly branches / 中华中医药杂志

The traditional Chinese medicine deduces the 'Tianshi'based on the chronological era by heavenly stems and earthly branches,whose mechanism has been an eternal mystery.The references discussed the astronomical background of the chronological record of years by heavenly stems and earthly branches.In this paper,① A new law of the nature and human body is unitied was discovered.The relative position of the diurnal motion of the sun and the motion of five yao observed from the earth repeated with a precise period of 60 years,(1years,=360days).It lead the discussion of astronomical background for the chronological record of days and shichen by heavenly stems and earthly branches.② The yiyi calendar's chronological record of months by heavenly stems and earthly branches had the same astronomical background as the chronological record of years,i.e.the relative positions of yearly motion of the sun,the synodic month and the motion of five yao observed from the earth had an approximate cycle time of 60 years.③ The paper further discovered that the relative positions of the diurnal and yearly motion of the sun,the synodic month and the motion of five yao observed from the earth repeated every 240 years.This indicated the astronomical background for the fact that the yiyi calendar's sizhu heavenly stems and earthly branches group had a cycle time of 240 years.④ The traditional Chinese medicine should use the yiyi calendar's local time.